Barzilai University Medical Center

28 Research Day 2020 Barzilai University Medical Center 15 RELATIONSHIP BETWEEN SELECTED POPULATIONS OF LEUKOCYTES AND CARDIOVASCULAR SYSTEM ACTIVITY IN WOMEN WITH ESSENTIAL HYPERTENSION Kuznik B.I. 1 , Davydov S.O. 1 , Guseva E.S. 1 , Stepanov A.V. 1 , Smolyakov Y.N. 1 , Fine I.V. 2 , Magen E 2 . 1 Chita State Medica Academy, Russia 2 Medicine C Department, Barzilai University Medical Center, Ben Gurion University of the Negev, Ashkelon, Israel Objective To investigate the effect of the quantitative ratios of different types of white blood cells on the different hemodynamic vascular response parameters of the cutaneous blood flow in healthy individuals and patients with essential hypertension (EH). Materials and methods The study was performed on 102 women suffering EH. The control group consisted of 30 healthy patients. The device Elfor 3 (Elfi-Tech Ltd.Rehovot, Israel) was used to measure different parameters of the cutaneous blood flow . The hemodynamic vascular response to the occlusion event may be used to evaluate the hyperemia response, which is one of the characteristics of endothelial functioning. Results In women with EH, both non-engaged (EH-1) and regularly engaged in kinesitherapy (EH-2), compared with the control group, the total content of leukocytes was increased, as well as the ratios of NEUTR/EOS, LYM/EOS, LYM/BAS and EOS/BAS. In hypertensive patients increased stroke volume and end-diastolic left ventricular volume, cardiac output, increased mass and the index of left ventricular mass were positively correlated with NEUTR/EOS, LYM/EOS and EOS/BAS. In EH-1 patients’ group, the balance of velocity distribution in the microcirculatory bed changes to fast interlayer processes was observed. In patients with EH-2, these changes were much less pronounced. In healthy women no significant relationships between leukocyte ratios and the level of systolic diastolic, mean, pulse pressure and hemodynamic indices were found. Conclusion These data suggest an important role of the relationship of various leukocyte populations in the pathogenesis of EH.