Barzilai University Medical Center

25 Research Day 2020 Barzilai University Medical Center 13 EPIDEMIOLOGY OF ACUTE PANCREATITIS IN SOUTHERN ISRAEL: A RETROSPECTIVE STUDY Ilya Polishchuk 1 , Demian Halperin 2, Ahmed Algedafy 1 , Jorge-Shmuel Delgado 3 , Mariana Zamir 4 , Doron Zamir 1 1 Department of Internal Medicine D, Barzilai University Medical Center, Ashkelon; Faculty of Health Sciences, Ben Gurion University, Beer Sheba, Israel 2 Department of Psychiatry, Barzilai University Medical Center, Ashkelon; Faculty of Health Sciences, Ben Gurion University, Beer Sheba, Israel 3 Gastroenterology Institute, Barzilai University Medical Center, Ashkelon; Faculty of Health Sciences, Ben Gurion University, Beer Sheba, Israel 4 Department of Dermatology, Hadassah Medical Center, Jerusalem, Israel Background There is a lack of information regarding acute pancreatitis in Israel. However, the most prevalent worldwide etiologic causes of acute pancreatitis are gallstones and alcohol abuse. Hypothesis Alcohol may be the most common cause for pancreatitis in our hospital, due to an increase in alcoholism in Ashkelon region Objective Delineate the prevalence, main causes, rate of recurrence, mortality, and complications of acute pancreatitis in southern Israel. Methods A retrospective study was performed, including the review of all medical charts of hospitalized patients diagnosed with acute pancreatitis during a 13-year period. Results 602 patients with "acute pancreatitis" were recorded (15:100,000 patients or 1.4:1000 admissions) during the time of the study. The main causes were: cholelithiasis (41.5%), alcohol (8.8%) and drugs (8.3%). Disothiazide was the most common drug associated with acute pancreatitis, followed by Sitagliptin, Angiotensin Converting Enzyme inhibitors (ACE) and Simvastatin. Undetermined etiology made up 33.6% of the cases. Recurrence rate was noted as 33.8% (alcohol 3.7%, hypertriglyceridemia 1.8%). This had no implications on mortality rate; Mortality rate stood at 4.3%. Bilateral pleural effusion, advanced CTSI grading, older age, and, especially, being unmarried were found to be poor prognostic predictive factors. Conclusions Biliary pancreatitis is the main cause of acute pancreatitis in southern Israel and constitutes a much more common etiology than alcohol. Furthermore, Drug-induced pancreatitis is a common etiology, with disothiazide being the most common drug associated with pancreatitis followed by ACE- Inhibitors, sitagliptin, and simvastatin. Recurrence of pancreatitis is common in this area, and older age, advanced CT staging, bilateral pleural effusion, as well as being unmarried are all poor prognostic predictive factor.