Barzilai University Medical Center

124 Research Day 2020 Barzilai University Medical Center 89 MANTLE CELL LYMPHOMA OF THE ORAL CAVITY: AN UNCOMMON SITE FOR AN UNCOMMON LESION, TWO NEW CASES AND LITERATURE REVIEW Ludmila Lukach 1 , Hadas Lehman 2 , Alejandro Livoff 3 , Oded Nahlieli 4,5 , Eli Michaeli 1 , Irit Allon 1,5 1 Oral Medicine Unit, Barzilai University Medical Center, Ashkelon, Israel 2 Oral and Maxillofacial Unit, Shaare Zedek Medical Center, Jerusalem, Israel 3 Institute of Pathology, Barzilai University Medical Center, Ashkelon, Israel 4 Department of Oral & Maxillofacial Surgery, Barzilai University Medical Center, Ashkelon, Israel 5 Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel Background Mantle cell lymphoma (MCL) is an uncommon intermediate grade B cell lymphoma rarely occurring in the oral cavity. Hypothesis MCL of the oral cavity may present as bi/multifocal lesions and are rarely considered in the clinical differential diagnosis. This lesion should be better characterized. Objectives Two case presentations from our archives alongside a literature review on this entity in this particular location were performed. In total, seventeen cases of intra- oral MCL were analyzed. Results Clinically, MCL mostly presents as a painless soft non-ulcerated mass. Males are affected more often than females (11/17 cases, 68.8%). The median age was 69 years for males and 62.5 for females. The hard palate was the most common site of occurrence. Interestingly, only half of the cases were solitary and the other half multi-focal. In at least 10 cases (62%) the oral involvement was the first presentation of MCL. In all cases, the small to medium lymphocytes were observed and stained positive for CD20 and Cyclin D1. Twelve cases were CD5 positive, and two were CD5 negative. Verification of the typical chromosomal translocation t (11:14) (q13;32) was performed in only four cases and was carried out with FISH analysis. The treatment regimen was not uniform and was influenced by different factors such as patient age and comorbidities. Conclusions MCL is a rare entity in the oral cavity. The most common presentation is a non - ulcerated uni or bilateral palatal mass in an old male patient. In more than half of the cases the oral presentation is the first sign of the disease. It is important to be familiar with this rare entity and to establish an early diagnosis that might improve the patient’s prognosis and treatment outcome.