Barzilai University Medical Center

101 Research Day 2020 Barzilai University Medical Center 73 LUNG FUNCTION DETERIORATION PREDICTS ELEVATED TROPONIN LEVEL IN APPARENTLY HEALTHY POPULATION WITH 5 YEARS FOLLOW UP Amir Bar-Shai 1 , Mor Krubiner 1 , Breslavsky A. 1 , Udi Shapira 2 , David Zeltser 2 , Itzhak Shapira 2 , Shlomo Berliner 2 , Ori Rogowski 2 and Shani Shenhar-Tsarfaty 2 1 Division of Pulmonary Medicine, Barzilai University Medical Center and Faculty of Health Sciences, Ben-Gurion University, Ashkelon, Israel. 2 Internal Medicine "C, "D and "E, The Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Background Lung function is inversely associated with coronary heart disease and cardio-vascular disease. Highly sensitive cardiac troponin (hs-cTnT) was recently found to represent early subclinical cardiac disease even in healthy individuals. We therefore thought to explore the inter-relationship between lung function status, hs-cTnT and the correlation between changes over time in these two measures. Methods Apparently healthy individuals from the Tel-Aviv-Medical-Center-Inflammatory-Survey (TAMCIS) where classified to two groups of normal values of FVC % predicted and FEV1% predicted (n=850;824, respectively) and abnormal values (n=44;70, respectively). We compared the hs-cTnT levels between the two groups. Next, we selected participants with normal lung function and prospectively followed them for mean follow-up of 5 years in order to evaluate the effect of lung function deterioration on hs-cTnT levels. Last, we evaluated the correlation between deterioration in FEV1 % predicted and an increase in hs-cTnT over one year of follow up. Results Subjects with abnormal values of FVC or FEV1 presented higher hs-cTnT levels compared to subjects with normal values (9.6±3.4 ng/L compared to 5.74±0.3, p=0.030 for FVC; 8.2±2.3 compared to 5.7±0.3, p= 0.028 for FEV1). In 2,618 subjects with normal lung function at baseline, lung function deterioration above 5% in 5 years follow up, were in increased risk to have hs-cTnT above 5 ng/L (OR= 1.67 (1.222 - 2.099, p value=0.001), and delta FEV1 between two consecutive visits was inversely correlated with the increase of hs-cTnT (r=-0.244, p<0.001). Conclusions Deterioration of FVC or FEV1 in lung function predicts elevated troponin level and may be a sign of early subclinical cardiac disease.